Bone marrow
transplant
It is a very much expansive treatment for the prevention of all
types of Thalassemia. Bone marrow transplantation may offer the possibility of
a cure in young people who have an HLA-matched donor. Success rates have been
in the 80–90% ra
nge. Mortality from the procedure is about 3%. There are no
randomized controlled trials which have tested the safety and efficacy of
non-identical donor bone marrow transplantation in persons with β- Thalassemia
who are dependent on blood transfusion.
If the person does not have an HLA-matched compatible donor,
another method called bone marrow transplantation (BMT) from haploidentical
mother to child (mismatched donor) may be used. In a study of 31 people, the
thalassemia-free survival rate 70%, rejection 23%, and mortality 7%. The best
results are with very young people.
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